Do older adults require more leucine to stimulate muscle protein synthesis?
A recent large-scale study challenged the long-held belief that older adults need more leucine to stimulate muscle protein synthesis. Contrary to 17-year-old research suggesting older adults had "anabolic resistance" to amino acids, this new study found that healthy older adults (ages 65-85) responded normally to a small dose of essential amino acids containing just 1.77g of leucine. The researchers concluded that healthy aging itself doesn't cause amino acid resistance, and adequate dietary protein should be sufficient to maintain muscle mass in older adults.
Essential amino acids and muscle protein recovery from resistance exercise
Do increased levels of EAAs alone stimulate muscle protein synthesis (MPS)?
Are carbohydrates required at the same time?
Is insulin responsible f...
Metabolic Evaluation of the Dietary Guidelines’ Ounce Equivalents of Protein Food Sources in Young Adults: A Randomized Controlled Trial
Is egg protein and peanut protein really equivalent?
Well, the USDA's Dietary guidelines for Americans (DGA) seems to think so. The authors of the ...
Latency and duration of stimulation of human muscle protein synthesis during continuous infusion of amino acids
If essential amino acids (EAAs) stimulate muscle protein synthesis (MPS), can we just sip on them all day long to keep our EAA levels high and buil...
The underappreciated role of muscle in health and disease
Muscle mass isn't just for bodybuilders and athletes!
Instead, muscle mass acts as the primary "reservoir" for amino acids in the body to maintain ...
Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion
Which provides a greater anabolic effect: an EAA supplement or a mixed-meal containing an equivalent amount of EAAs? What is the effect of EAA supp...
Dietary essential amino acids are highly anabolic in pediatric patients with cystic fibrosis
Muscle mass loss is present in 25–30% of children with Cystic Fibrosis and is associated with reduced lung function and bone mineral loss. Could EA...
Regulation of muscle protein by amino acids
What regulates muscle protein synthesis? Exercise, nutrition, both?
This study concludes that "plasma concentrations of EAA regulate muscle protein...
Whey protein and essential amino acids promote the reduction of adipose tissue
Weight loss strategies for obese, elderly individuals face multifaceted clinical challenges as the mortality risk of muscle loss may exceed the pot...
Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
Objective: We assessed whether nonessential amino acids are required in a nutritional supplement to stimulate muscle protein anabolism in the elder...
Amino acid ingestion improves muscle protein synthesis in the young and elderly
Can both young and old benefit from EAAs? Yes!
In this study, researchers concluded that "although the influence of insulin and the time course of ...
An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein
We conclude that the stimulatory effect of exogenous amino acids on muscle protein synthesis is enhanced by prior exercise, perhaps in part becaus...
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