Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers

Since EAA supplements lack the nonessential amino acids (NEAAs) found in intact dietary protein, does this negatively affect muscle protein synthesis? No - as the title of this paper states, nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers.

"We conclude that ingestion of a solution composed of carbohydrates to stimulate insulin release and a small amount of essential amino acids to increase amino acid availability for protein synthesis is an effective stimulator of muscle protein anabolism." 

Read the full text here: https://doi.org/10.1016/s0955-2863(98)00087-4

Tipton KD, Gurkin BE, Matin S, Wolfe RR. Nonessential amino acids are not necessary to stimulate net muscle protein synthesis in healthy volunteers. J Nutr Biochem. 1999 Feb;10(2):89-95. doi: 10.1016/s0955-2863(98)00087-4. PMID: 15539275.