Research shows that creatine and HMB have additive (synergistic) effects on lean body mass and strength, potentially acting through different mechanisms. Key studies include:

• A three-week study demonstrated that creatine plus HMB groups showed significant increases in lean body mass compared to placebo, with additive effects suggesting different mechanisms of action.
• A year-long study of 117 older adults found that HMB plus Vitamin D supplementation significantly increased lean mass and improved functional performance even without exercise.
• Research on post-surgical recovery showed that HMB + Vitamin D3 + protein supplementation improved mobility and strength within 30 days after hip fracture surgery.

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