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Yes! Creatine and HMB do not interfere with OptimalAmino® at all. HMB is a metabolite of leucine, and creatine is an amino acid derivative naturally produced in the body from glycine and arginine.
You can mix them with OptimalAmino® or take OptimalAmino® before your workout and creatine/HMB after.
For the purest, most effectively dosed option, see OptimalStack® — the first and only creatine/HMB combination product in the world to achieve NSF Certified for Sport® certification. It combines 5g of ultra-pure Creapure® creatine monohydrate with 3g myHMB®/D3.